Reconstructing Recombination Network from Sequence Data: The Small Parsimony Problem

  • Authors:
  • C. Thach Nguyen;Nguyen Bao Nguyen;Wing-Kin Sung;Louxin Zhang

  • Affiliations:
  • -;-;-;-

  • Venue:
  • IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
  • Year:
  • 2007

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Abstract

The small parsimony problem is studied for reconstructing recombination networks from sequence data. The small parsimony problem is polynomial-time solvable for phylogenetic trees. However, the problem is proved NP-hard even for galled recombination networks. A dynamic programming algorithm is also developed to solve the small parsimony problem. It takes $O(dn2^{3h})$ time on an input recombination network over length-$d$ sequences in which there are $h$ recombination and $n - h$ tree nodes.