Multiscale analysis of short term heart beat interval, arterial blood pressure, and instantaneous lung volume time series

  • Authors:
  • Leonardo Angelini;Roberto Maestri;Daniele Marinazzo;Luigi Nitti;Mario Pellicoro;Gian Domenico Pinna;Sebastiano Stramaglia;Salvatore A. Tupputi

  • Affiliations:
  • TIRES-Center of Innovative Technologies for Signal Detection and Processing, University of Bari, Via Amendola 173, 70126 Bari, Italy and Dipartimento Interateneo di Fisica, Via Amendola 173, 70126 ...;Dipartimento di Bioingegneria, Fondazione Salvatore Maugeri, IRCCS, Istituto Scientifico di Montescano, 27040 Montescano, Pavia, Italy;TIRES-Center of Innovative Technologies for Signal Detection and Processing, University of Bari, Via Amendola 173, 70126 Bari, Italy and Dipartimento Interateneo di Fisica, Via Amendola 173, 70126 ...;Dipartimento di Bioingegneria, Fondazione Salvatore Maugeri, IRCCS, Istituto Scientifico di Montescano, 27040 Montescano, Pavia, Italy;TIRES-Center of Innovative Technologies for Signal Detection and Processing, University of Bari, Via Amendola 173, 70126 Bari, Italy and Dipartimento Interateneo di Fisica, Via Amendola 173, 70126 ...;Dipartimento di Bioingegneria, Fondazione Salvatore Maugeri, IRCCS, Istituto Scientifico di Montescano, 27040 Montescano, Pavia, Italy;TIRES-Center of Innovative Technologies for Signal Detection and Processing, University of Bari, Via Amendola 173, 70126 Bari, Italy and Dipartimento Interateneo di Fisica, Via Amendola 173, 70126 ...;Dipartimento Interateneo di Fisica, Via Amendola 173, 70126 Bari, Italy

  • Venue:
  • Artificial Intelligence in Medicine
  • Year:
  • 2007

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Abstract

Motivations: Physiological systems are ruled by mechanisms operating across multiple temporal scales. A recently proposed approach, multiscale entropy analysis, measures the complexity at different time scales and has been successfully applied to long term electrocardiographic recordings. The purpose of this work is to show the applicability of this methodology, rooted on statistical physics ideas, to short term time series of simultaneously acquired samples of heart rate, blood pressure and lung volume, from healthy subjects and from subjects with chronic heart failure. In the same spirit, we also propose a multiscale approach, to evaluate interactions between time series, by performing a multivariate autoregressive (AR) modeling of the coarse grained time series. Methods: We apply the multiscale entropy analysis to our data set of short term recordings. Concerning the multiscale version of the multivariate AR approach, we apply it to the four dimensional time series so as to detect scale dependent patterns of interactions between the physiological quantities. Results: Evaluating the complexity of signals at the multiple time scales inherent in physiologic dynamics, we find new quantitative indicators which are statistically correlated with the pathology. Our results show that multiscale entropy calculated on all the measured quantities significantly differs (P