A Process Model of Rho GTP-binding Proteins in the Context of Phagocytosis

Authors:
Luca Cardelli;Philippa Gardner;Ozan Kahramanoğulları
Affiliations:
Microsoft Research, 7 JJ Thomson Avenue, CB3 0FB, Cambridge, UK;Department of Computing, Imperial College, London, UK;Department of Computing & Centre for Integrative Systems Biology, Imperial College, London, UK
Venue:
Electronic Notes in Theoretical Computer Science (ENTCS)
Year:
2008

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Abstract

At the early stages of the phagocytic signalling, Rho GTP-binding proteins play a key role. With the stimulus from the cell membrane and with the help from the regulators (GEF, GAP, Effector, GDI), these proteins serve as switches that interact with their environment in a complex manner. We present a generic process model for the Rho GTP-binding proteins, and compare it with a previous model that uses ordinary differential equations. We then extend the basic model to include the behaviour of the GDIs. We discuss the challenges this extension brings and directions of further research.