Organ transplantation policy evaluation (1995)

  • Authors:
  • A. Alan B. Pritsker;David L. Martin;Janet S. Reust;Mary Ann Wagner;O. Patrick Daily;Ann M. Harper;Erick B. Edwards;Leah E. Bennett;James R. Wilson;Michael E. Kuhl;John P. Roberts;Margaret D. Allen;James F. Burdick

  • Affiliations:
  • Pritsker Corporation, Indianapolis, Indiana;Pritsker Corporation, Indianapolis, Indiana;Pritsker Corporation, Indianapolis, Indiana;Pritsker Corporation, Indianapolis, Indiana;United Network for Organ Sharing, Richmond, Virginia;United Network for Organ Sharing, Richmond, Virginia;United Network for Organ Sharing, Richmond, Virginia;United Network for Organ Sharing, Richmond, Virginia;North Carolina State University, Raleigh, North Carolina;North Carolina State University, Raleigh, North Carolina;University of California, San Francisco, San Francisco, California;University of Washington Medical Center, Seattle, Washington;The Johns Hopkins University, Baltimore, Maryland

  • Venue:
  • Proceedings of the 39th conference on Winter simulation: 40 years! The best is yet to come
  • Year:
  • 2007

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Abstract

This paper on the UNOS Liver Allocation Model (ULAM) describes the building of a simulation model that supports policy evaluation for a national medical problem. The modeling and simulation techniques used in building ULAM include: fitting donor and patient arrival processes having trend and cyclic rate components using non-homogeneous Poisson processes (NHPPs) having exponential rate functions which may include both a polynomial and some trigonometric components; fitting distributions to data on transition times between states of medical urgency; application of variance reduction techniques using common random-number streams and prior information; organizing data structures for efficient file searching and ranking capabilities; the use of bootstrapping techniques for attribute sampling; the building of submodels employing biostatistical procedures such as Kaplan-Meier and logistic regression; and the characterization of performance measures within a complex political, economic and social environment. ULAM provides a means for producing quantitative information to support the selection of a liver allocation policy.