Model-free visualization of suspicious lesions in breast MRI based on supervised and unsupervised learning

Authors:
Thorsten Twellmann;Anke Meyer-Baese;Oliver Lange;Simon Foo;Tim W. Nattkemper
Affiliations:
Department of Electrical and Computer Engineering, Florida State University, Tallahassee, FL 32310-6046, USA and Applied Neuroinformatics Group, Faculty of Technology, Bielefeld University, Bielef ...;Department of Electrical and Computer Engineering, Florida State University, Tallahassee, FL 32310-6046, USA;Department of Electrical and Computer Engineering, Florida State University, Tallahassee, FL 32310-6046, USA;Department of Electrical and Computer Engineering, Florida State University, Tallahassee, FL 32310-6046, USA;Applied Neuroinformatics Group, Faculty of Technology, Bielefeld University, Bielefeld 33501, Germany
Venue:
Engineering Applications of Artificial Intelligence
Year:
2008

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Abstract

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has become an important tool in breast cancer diagnosis, but evaluation of multitemporal 3D image data holds new challenges for human observers. To aid the image analysis process, we apply supervised and unsupervised pattern recognition techniques for computing enhanced visualizations of suspicious lesions in breast MRI data. These techniques represent an important component of future sophisticated computer-aided diagnosis (CAD) systems and support the visual exploration of spatial and temporal features of DCE-MRI data stemming from patients with confirmed lesion diagnosis. By taking into account the heterogeneity of cancerous tissue, these techniques reveal signals with malignant, benign and normal kinetics. They also provide a regional subclassification of pathological breast tissue, which is the basis for pseudo-color presentations of the image data. Intelligent medical systems are expected to have substantial implications in healthcare politics by contributing to the diagnosis of indeterminate breast lesions by non-invasive imaging.