On distance and similarity in fold space

  • Authors:
  • Manfred J. Sippl

  • Affiliations:
  • -

  • Venue:
  • Bioinformatics
  • Year:
  • 2008

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Abstract

Summary: Metric information on similarities and distances in fold space is essential for quantitative work in structural bioinformatics and structural biology. Here we derive a suitable metric for protein structures from the fundamental axioms of similarity. Derivation of the metric also clarifies the relationship between the interrelated concepts of distance and similarity. Contact: sippl@came.sbg.ac.at