Computer simulation of intracardiac potential with whole-heart model

Authors:
Xin Zhu;Daming Wei
Affiliations:
Graduate Department of Information Systems, University of Aizu, Aizu-Wakamatsu City, Fukushima Prefecture 965-8580, Japan.;Graduate Department of Information Systems, University of Aizu, Aizu-Wakamatsu City, Fukushima Prefecture 965-8580, Japan
Venue:
International Journal of Bioinformatics Research and Applications
Year:
2007

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Abstract

Computer simulation of intracardiac potentials was performed based on a whole-heart model, emphasising applications to Electrophysiology Study (EPS) and catheter ablation. A numerical method was proposed based on a volume conductor model with multiple interfaces and piecewise homogeneity. A model of a normal heart and a model of Wolff-Parkinson-White (WPW) Syndrome with a right free-wall Accessory Pathway (AP) were employed to simulate intracardiac electrograms. The study was validated by comparing the simulated electrograms with those in catheter-based EPS and ablations. Applying whole-heart modelling to the EPS and ablation is regarded as a new direction of electrocardiologic forward problem.