Making large-scale support vector machine learning practical
Advances in kernel methods
Gene functional classification from heterogeneous data
RECOMB '01 Proceedings of the fifth annual international conference on Computational biology
Transductive Inference for Text Classification using Support Vector Machines
ICML '99 Proceedings of the Sixteenth International Conference on Machine Learning
Using the Fisher Kernel Method to Detect Remote Protein Homologies
Proceedings of the Seventh International Conference on Intelligent Systems for Molecular Biology
Iterative Weighting of Phylogenetic Profiles Increases Classification Accuracy
ICMLA '05 Proceedings of the Fourth International Conference on Machine Learning and Applications
Modeling adaptive kernels from probabilistic phylogenetic trees
Artificial Intelligence in Medicine
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We proposed a novel method for protein classification based on phylogenetic profiles. Each protein's profile was extended with extra bits encoding the phylogenetic tree structure and the likelihood, in the form of weights on profile indices, of the protein's functional family membership in each of the reference genomes. The extended profiles were then integrated as part of a kernel of a support vector machine, which was trained in a transductive learning scheme using the EM algorithm to update the weights. Classification accuracy was greatly increased when tested on the proteome of Saccharomyces cerevisiae using the MIPS classification as a benchmark.