Tensor-Based Analysis of Genetic Influences on Brain Integrity Using DTI in 100 Twins
MICCAI '09 Proceedings of the 12th International Conference on Medical Image Computing and Computer-Assisted Intervention: Part I
The multivariate A/C/E model and the genetics of fiber architecture
ISBI'09 Proceedings of the Sixth IEEE international conference on Symposium on Biomedical Imaging: From Nano to Macro
Multivariate variance-components analysis in DTI
ISBI'10 Proceedings of the 2010 IEEE international conference on Biomedical imaging: from nano to Macro
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Diffusion tensor magnetic resonance imaging (DTI) reveals the local orientation and integrity of white matter fiber structure based on imaging multidirectional water diffusion. Group differences in DTI images are often computed from single scalar measures, e.g., the Fractional Anisotropy (FA), discarding much of the information in the 6-parameter symmetric diffusion tensor. Here, we compute multivariate 6D tensor statistics to detect brain morphological changes in 12 blind subjects versus 14 sighted controls. After Log-Euclidean tensor denoising, images were fluidly registered to a common template. Fluidly-convected tensor signals were re-oriented by applying the local rotational and translational component of the deformation. Since symmetric, positive-definite matrices form a non-Euclidean manifold, we applied a Riemannian manifold version of the Hotelling's T 2 test to the logarithms of the tensors, using a log-Euclidean metric. Statistics on the full 6D tensor-valued images outperformed univariate analysis of scalar images, such as the FA and the geodesic anisotropy (GA).