Mitotic HEp-2 cells recognition under class skew
ICIAP'11 Proceedings of the 16th international conference on Image analysis and processing - Volume Part II
HEp-2 cell pattern segmentation for the support of autoimmune disease diagnosis
Proceedings of the 4th International Symposium on Applied Sciences in Biomedical and Communication Technologies
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Indirect immunofluorescence (IIF) with HEp-2 cells is used for the detection of antinuclear autoantibodies (ANA) in systemic autoimmune diseases. An automatic inspection system for ANA testing can be divided into HEp-2 cell detection, fluorescence pattern classification and computer aided diagnosis phases. This study focused on the first phase of cell detecting and locating. This study presented an adaptive edged-based segmentation method for automatically detecting outlines of fluorescence cells in IIF images. The proposed method evaluated 2573 cells with six distinct fluorescence patterns from 45 images. The results of computer simulations revealed that the proposed method always identified cell outlines as were obtained by manual sketched. Such a method provides robust and fast automatic segmentation of HEp-2 fluorescent patterns in ANA testing.