Gene tree labeling using nonnegative matrix factorization on biomedical literature

Authors:
Kevin E. Heinrich;Michael W. Berry;Ramin Homayouni
Affiliations:
Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN;Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN;Department of Biology, University of Memphis, Memphis, TN
Venue:
Computational Intelligence and Neuroscience - Advances in Nonnegative Matrix and Tensor Factorization
Year:
2008

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Abstract

Identifying functional groups of genes is a challenging problem for biological applications. Text mining approaches can be used to build hierarchical clusters or trees from the information in the biological literature. In particular, the nonnegative matrix factorization (NMF) is examined as one approach to label hierarchical trees. A generic labeling algorithm as well as an evaluation technique is proposed, and the effects of different NMF parameters with regard to convergence and labeling accuracy are discussed. The primary goals of this study are to provide a qualitative assessment of the NMF and its various parameters and initialization, to provide an automated way to classify biomedical data, and to provide a method for evaluating labeled data assuming a static input tree. As a byproduct, a method for generating gold standard trees is proposed.