The effects of mutation and directed intervention crossover when applied to scheduling chemotherapy

Authors:
Paul M. Godley;David E. Cairns;Julie Cowie;Kevin M. Swingler;John McCall
Affiliations:
University of Stirling, Stirling, Scotland, Uk;University of Stirling, Stirling, Scotland, Uk;University Of Stirling, Stirling, Scotland, Uk;University of Stirling, Stirling, Scotland, Uk;The Robert Gordon University, Aberdeen, Scotland, Uk
Venue:
Proceedings of the 10th annual conference on Genetic and evolutionary computation
Year:
2008

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Abstract

This paper discusses the effects of mutation and directed intervention crossover approaches when applied to the derivation of cancer chemotherapy treatment schedules. Unlike traditional Uniform Crossover (UC), the directed intervention techniques actively choose the intervention level based on the fitness of the parents selected for crossover. This work describes how directed intervention crossover principles are more robust to mutation and lead to significant improvement over UC when applied to cancer chemotherapy treatment scheduling.