Microarray Gridding by Mathematical Morphology
SIBGRAPI '01 Proceedings of the 14th Brazilian Symposium on Computer Graphics and Image Processing
Gridding and Compression of Microarray Images
CSB '04 Proceedings of the 2004 IEEE Computational Systems Bioinformatics Conference
DNA Microarray Image Analysis Using Active Contour Model
CSB '04 Proceedings of the 2004 IEEE Computational Systems Bioinformatics Conference
Blind Microarray Gridding: A New Framework
IEEE Transactions on Systems, Man, and Cybernetics, Part C: Applications and Reviews
Gridline: automatic grid alignment DNA microarray scans
IEEE Transactions on Image Processing
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A novel algorithm for detecting microarray subgrids is proposed. The only input to the algorithm is the raw microarray image, which can be of any resolution, and the subgrid detection is performed with no prior assumptions. The algorithm consists of a series of methods of spot shape detection, spot filtering, spot spacing estimation, and subgrid shape detection. It is shown to be able to divide images of varying quality into subgrid regions with no manual interaction. The algorithm is robust against high levels of noise and high percentages of poorly expressed or missing spots. In addition, it is proved to be effective in locating regular groupings of primitives in a set of non-microarray images, suggesting potential application in the general area of image processing.