The study of drug-reaction relationships using global optimization techniques

Authors:
M. A. Mammadov;A. M. Rubinov;J. Yearwood
Affiliations:
University of Ballarat, Ballarat, Victoria, Australia;University of Ballarat, Ballarat, Victoria, Australia;University of Ballarat, Ballarat, Victoria, Australia
Venue:
Optimization Methods & Software - Systems Analysis, Optimization and Data Mining in Biomedicine
Year:
2007

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Abstract

In this paper we develop an optimization approach for the study of adverse drug reaction (ADR) problems. This approach is based on drug-reaction relationships represented in the form of a vector of weights, which can be defined as a solution to some global optimization problem. Although it can be used for solving many ADR problems, we concentrate on two of them here: the accurate identification of drugs that are responsible for reactions that have occurred, and drug-drug interactions. Based on drug-reaction relationships, we formulate these problems as an optimization problem. The approach is applied to cardiovascularn-type reactions from the Australian Adverse Drug Reaction Advisory Committee (ADRAC) database. Software based on this approach has been developed and could have beneficial use in prescribing.