Architectural mismatch or why it's hard to build systems out of existing parts
Proceedings of the 17th international conference on Software engineering
Model composability: formulating a research thrust: composable simulations
Proceedings of the 32nd conference on Winter simulation
Proceedings of the 35th conference on Winter simulation: driving innovation
The potential coupling interface: metadata for model coupling
WSC '04 Proceedings of the 36th conference on Winter simulation
Foundations of validating reusable behavioral models in engineering design problems
WSC '04 Proceedings of the 36th conference on Winter simulation
A case study of model context for simulation composability and reusability
WSC '05 Proceedings of the 37th conference on Winter simulation
The role of composition and aggregation in modeling macromolecular regulatory networks
Proceedings of the 38th conference on Winter simulation
Model Composition for Macromolecular Regulatory Networks
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
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Today's macromolecular regulatory network models are small compared to the amount of information known about the corresponding cellular pathways, in part because current modeling languages and tools are unable to handle significantly larger models. Most pathway models are small models of individual pathways which are relatively easy to construct and manage. The hope is someday to put these pieces together to create a more complete picture of the underlying molecular machinery. While efforts to make large models can benefit from reusing existing components, there currently exists little tool or representational support for combining or composing models. In this paper we present a tool for merging two or more models (we call this process model fusion) and a concrete proposal for implementing composition in the context of the Systems Biology Markup Language (SBML).