A Novel Hybrid GMM/SVM Architecture for Protein Secondary Structure Prediction

  • Authors:
  • Emad Bahrami Samani;M. Mehdi Homayounpour;Hong Gu

  • Affiliations:
  • Computer Engineering and IT Department, Amirkabir University of Technology, Tehran, Iran;Computer Engineering and IT Department, Amirkabir University of Technology, Tehran, Iran;Department of Mathematics and Statistics, Dalhousie University, Halifax, NS, Canada

  • Venue:
  • WILF '07 Proceedings of the 7th international workshop on Fuzzy Logic and Applications: Applications of Fuzzy Sets Theory
  • Year:
  • 2007

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Abstract

The problem of secondary structure prediction can be formulated as a pattern classification problem and methods from statistics and machine learning are suitable. This paper proposes a new combination approach between Gaussian Mixture Model (GMM) and Support Vector Machine (SVM) by typical sample extraction based on a UBM/GMM system for SVM in protein secondary structure prediction. Our hybrid model achieved a good performance of three-state overall per residue accuracyQ3= 77.6%which is comparable to the best techniques available.