A Hybrid Model of Sprouting Angiogenesis

Authors:
Florian Milde;Michael Bergdorf;Petros Koumoutsakos
Affiliations:
Computational Science, ETH Zürich, Switzerland CH-8092;Computational Science, ETH Zürich, Switzerland CH-8092;Computational Science, ETH Zürich, Switzerland CH-8092
Venue:
ICCS '08 Proceedings of the 8th international conference on Computational Science, Part II
Year:
2008

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Abstract

We present a computational model of tumor induced sprouting angiogenesis that involves a novel coupling of particle-continuum descriptions. The present 3D model of sprouting angiogenesis accounts for the effect of the extracellular matrix on capillary growth and considers both soluble and matrix-bound growth factors. The results of the simulations emphasize the role of the extracellular matrix and the different VEGF isoforms on branching behavior and the morphology of generated vascular networks.