Fully Automatic Heart Beat Rate Determination in Digital Video Recordings of Rat Embryos

Authors:
M. Khalid Khan;Mats F. Nilsson;Bengt R. Danielsson;Ewert Bengtsson
Affiliations:
Centre for Image Analysis, Uppsala University, Sweden;Department of Pharmaceutical Biosciences, Division of Toxicology, Uppsala University, Sweden;Department of Pharmaceutical Biosciences, Division of Toxicology, Uppsala University, Sweden;Centre for Image Analysis, Uppsala University, Sweden
Venue:
MDA '08 Proceedings of the 3rd international conference on Advances in Mass Data Analysis of Images and Signals in Medicine, Biotechnology, Chemistry and Food Industry
Year:
2008

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Abstract

Embryo cultures of rodents is an established technique for monitoring adverse effects of chemicals on embryonic development. The assessment involves determination of the heart rate of the embryo which is usually done visually, a technique which is tedious and error prone. We present a new method for fully automatic heart detection in digital videos of rat embryos. First it detects the heart location, and then it counts the number of heart beats for a predetermined period of time. Using this automated method many more embryos can be evaluated at reasonable cost.