Validation of Cone-Beam CT Measurements of Tumour Burden Using Three-Dimensional Histopathology: Initial Results For a Lumpectomy

Authors:
G. M. Clarke;J. G. Mainprize;C. Peressotti;L. Sun;D. Wang;J. T. Zubovits;C. M. Holloway;G. J. Czarnota;M. J. Yaffe
Affiliations:
Imaging Research,;Imaging Research,;Imaging Research,;Imaging Research,;Imaging Research,;Department of Pathology, Sunnybrook Health Sciences Centre, Toronto,;Department of Surgery, Sunnybrook Health Sciences Centre, Toronto,;Department of Radiation Oncology, Sunnybrook Health Sciences Centre,;Imaging Research, and Departments of Medical Imaging and Medical Biophysics, University of Toronto, Toronto,
Venue:
IWDM '08 Proceedings of the 9th international workshop on Digital Mammography
Year:
2008

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Abstract

Tumour size is an important prognostic indicator in breast cancer. This is typically measured as a simple linear diameter, although tumour volume may be a better surrogate of tumour burden. We have been optimizing techniques for three-dimensional histopathology based on digital scanning light microscopy of whole-mount, whole-specimen serial sections. We apply this to validate tumour volume measurements obtained using specimen cone-beam CT imaging. We demonstrate initial results for this technique using one lumpectomy and then show examples of how this technique can serve as a `gateway' to validating emerging functional and molecular imaging modalities.