Modelling the Tunability of Early T Cell Signalling Events

Authors:
Nick D. Owens;Jon Timmis;Andrew Greensted;Andy Tyrrell
Affiliations:
Department of Electronics, University of York, UK;Department of Electronics, University of York, UK and Department of Computer Science, University of York, UK;Department of Electronics, University of York, UK;Department of Electronics, University of York, UK
Venue:
ICARIS '08 Proceedings of the 7th international conference on Artificial Immune Systems
Year:
2008

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Abstract

The Tunable Activation Threshold hypothesis of T Cells is investigated through computational modelling of T cell signalling pathways. Modelling techniques involving the ï戮驴-calculus and the PRISM model checker are presented, and are applied to produce a stochastic model of T cell signalling. Initial results which demonstrate tuning of T cells are presented.