The Pathways of Complement

Authors:
Jonathan M. Aitken;Tim Clarke;Jonathan I. Timmis
Affiliations:
Department of Electronics, University of York, Heslington, York, UK YO10 5DD;Department of Electronics, University of York, Heslington, York, UK YO10 5DD;Department of Electronics, University of York, Heslington, York, UK YO10 5DD
Venue:
ICARIS '08 Proceedings of the 7th international conference on Artificial Immune Systems
Year:
2008

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Abstract

The natural world has developed very effective methods for dealing with pathogens that are invading an organism. By taking inspiration from the in-built, innate, response this paper develops a new algorithm that mimics activation path of the Alternative Pathway of Complement. The Alternative Pathway is triggered by cell surfaces. If the surfaces display safe characteristics then a strong suppression process prevents activation. In the case of non-safe surfaces a positive feedback loop rapidly identifies the location marking it for removal by phagocytosis.