A Stochastic Multi-agent Model of Stem Cell Proliferation

Authors:
Richard C. Wath;Pietro Liò
Affiliations:
The Computer Laboratory, University of Cambridge, Cambridge, UK CB3 0FD;The Computer Laboratory, University of Cambridge, Cambridge, UK CB3 0FD
Venue:
ACRI '08 Proceedings of the 8th international conference on Cellular Automata for Reseach and Industry
Year:
2008

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Experiences creating three implementations of the repast agent modeling toolkit

ACM Transactions on Modeling and Computer Simulation (TOMACS)

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Abstract

In this paper we describe a Multi-Agent framework to model the dynamics of self-renewing and differentiating stem cells. Our model is extended to an effective stochastic simulator of 5-bromo-2-deoxyuridine (BrdU) uptake and loss on different detection thresholds. Matching the results of an existing BrdU model validates our effort. Additionally our Multi-Agent approach enables much more statistically rich analysis and provides a modelling platform stem cell scientists can easily understand and relate to.