Identification of Co-regulated Signature Genes in Pancreas Cancer- A Data Mining Approach

Authors:
K. R. Seeja;M. A. Alam;S. K. Jain
Affiliations:
Department of Computer Science, Hamdard University, NewDelhi, India;Department of Biotechnology, Hamdard University, NewDelhi, India;Department of Biotechnology, Hamdard University, NewDelhi, India
Venue:
ICIC '08 Proceedings of the 4th international conference on Intelligent Computing: Advanced Intelligent Computing Theories and Applications - with Aspects of Theoretical and Methodological Issues
Year:
2008

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Abstract

Pancreas cancer is one of the most fatal among the cancers. The mortality rate is high due to the lack of tools for proper diagnosis and effective therapeutics. Identification of changes in gene expression in pancreas cancer may lead to the development of novel tools for diagnosis and effective treatment methodology. In this paper we present an association rule mining approach to identify the association between the genes that are either over expressed or under expressed in pancreas cancer compared to normal pancreas. We have used the SAGE data related to pancreas cancer. It is expected that the results will help in developing better treatment methodology for pancreas cancer and also for designing a low cost microarray chip for diagnosing pancreas cancer. The results have been validated in terms of Gene Ontology and the signature genes have been identified that match with published data.