A Distributed Spatio-temporal EEG/MEG Inverse Solver

  • Authors:
  • Wanmei Ou;Polina Golland;Matti Hämäläinen

  • Affiliations:
  • Computer Science and Artificial Intelligence Laboratory, MIT, , USA;Computer Science and Artificial Intelligence Laboratory, MIT, , USA;Athinoula A. Martinos Center for Biomedical Imaging, MGH, , USA

  • Venue:
  • MICCAI '08 Proceedings of the 11th international conference on Medical Image Computing and Computer-Assisted Intervention - Part I
  • Year:
  • 2008

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Abstract

We propose a novel 茂戮驴1茂戮驴2-norm inverse solver for estimating the sources of EEG/MEG signals. Based on the standard 茂戮驴1-norm inverse solver, the proposed sparse distributed inverse solver integrates the 茂戮驴1-norm spatial model with a temporal model of the source signals in order to avoid unstable activation patterns and "spiky" reconstructed signals often produced by the original solvers. The joint spatio-temporal model leads to a cost function with an 茂戮驴1茂戮驴2-norm regularizer whose minimization can be reduced to a convex second-order cone programming problem and efficiently solved using the interior-point method. Validation with simulated and real MEG data shows that the proposed solver yields source time course estimates qualitatively similar to those obtained through dipole fitting, but without the need to specify the number of dipole sources in advance. Furthermore, the 茂戮驴1茂戮驴2-norm solver achieves fewer false positives and a better representation of the source locations than the conventional 茂戮驴2minimum-norm estimates.