Model-Based Segmentation of Hippocampal Subfields in Ultra-High Resolution In Vivo MRI

Authors:
Koen Leemput;Akram Bakkour;Thomas Benner;Graham Wiggins;Lawrence L. Wald;Jean Augustinack;Bradford C. Dickerson;Polina Golland;Bruce Fischl
Affiliations:
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, , USA and Computer Science and Artificial Intelligence Laboratory, MIT, USA;Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, , USA and Department of Neurology, MGH, Harvard Medical School, USA;Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, , USA;Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, , USA;Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, , USA and Harvard-MIT Division of Health Sciences and Technology, MIT, USA;Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, , USA;Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, , USA and Department of Neurology, MGH, Harvard Medical School, USA;Computer Science and Artificial Intelligence Laboratory, MIT, USA;Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, , USA and Computer Science and Artificial Intelligence Laboratory, MIT, USA and Harvard-M ...
Venue:
MICCAI '08 Proceedings of the 11th international conference on Medical Image Computing and Computer-Assisted Intervention - Part I
Year:
2008

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Abstract

Recent developments in MR data acquisition technology are starting to yield images that show anatomical features of the hippocampal formation at an unprecedented level of detail, providing the basis for hippocampal subfield measurement. Because of the role of the hippocampus in human memory and its implication in a variety of disorders and conditions, the ability to reliably and efficiently quantify its subfields through in vivo neuroimaging is of great interest to both basic neuroscience and clinical research. In this paper, we propose a fully-automated method for segmenting the hippocampal subfields in ultra-high resolution MRI data. Using a Bayesian approach, we build a computational model of how images around the hippocampal area are generated, and use this model to obtain automated segmentations. We validate the proposed technique by comparing our segmentation results with corresponding manual delineations in ultra-high resolution MRI scans of five individuals.