Cortical Surface Thickness as a Classifier: Boosting for Autism Classification

  • Authors:
  • Vikas Singh;Lopamudra Mukherjee;Moo K. Chung

  • Affiliations:
  • Biostatistics and Medical Informatics, University of Wisconsin-Madison,;Computer Science & Engineering, State University of New York at Buffalo,;Biostatistics and Medical Informatics, University of Wisconsin-Madison,

  • Venue:
  • MICCAI '08 Proceedings of the 11th international conference on Medical Image Computing and Computer-Assisted Intervention - Part I
  • Year:
  • 2008

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Abstract

We study the problem of classifying an autistic group from controls using structural image data alone, a task that requires a clinical interview with a psychologist. Because of the highly convoluted brain surface topology, feature extraction poses the first obstacle. A clinically relevant measure called the cortical thickness has shown promise but yields a rather challenging learning problem --- where the dimensionality of the distribution is extremely large and the training set is small. By observing that each point on the brain cortical surface may be treated as a "hypothesis", we propose a new algorithm for LPBoosting (with truncated neighborhoods) for this problem. In addition to learning a high quality classifier, our model incorporates topological priors into the classification framework directly --- that two neighboring points on the cortical surface (hypothesis pairs) must have similar discriminative qualities. As a result, we obtain not just a label { + 1, 茂戮驴 1} for test items, but also an indication of the "discriminative regions" on the cortical surface. We discuss the formulation and present interesting experimental results.