Inversion Medians Outperform Breakpoint Medians in Phylogeny Reconstruction from Gene-Order Data
WABI '02 Proceedings of the Second International Workshop on Algorithms in Bioinformatics
INFORMS Journal on Computing
Multichromosomal Genome Median and Halving Problems
WABI '08 Proceedings of the 8th international workshop on Algorithms in Bioinformatics
Decompositions of Multiple Breakpoint Graphs and Rapid Exact Solutions to the Median Problem
WABI '08 Proceedings of the 8th international workshop on Algorithms in Bioinformatics
Reactive stochastic local search algorithms for the genomic median problem
EvoCOP'08 Proceedings of the 8th European conference on Evolutionary computation in combinatorial optimization
Yeast Ancestral Genome Reconstructions: The Possibilities of Computational Methods
RECOMB-CG '09 Proceedings of the International Workshop on Comparative Genomics
RECOMB-CG '09 Proceedings of the International Workshop on Comparative Genomics
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In a previous paper, we have shown that adequate subgraphs can be used to decompose multiple breakpoint graphs, achieving a dramatic speedup in solving the median problem. In this paper, focusing on the median of three problem, we prove more important properties about adequate subgraphs with rank 3 and discuss the algorithms inventorying simple adequate subgraphs. After finding simple adequate subgraphs of small sizes, we incorporate them into ASMedian, an algorithm to solve the median of three problem. Results on simulated data show dramatic speedup so that many instances can be solved very quickly, even ones containing hundreds or thousands of genes.