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Five years ago, Healthwise began transitioning into an Agile and Lean organization. In 2007, four years after introduction to Agile, Healthwise was identified by the Wall Street Journal as one of the top 15 small employers in the United States [1]. Healthwise uses Scrum and Lean principles to manage multi-disciplinary product development teams. Teams create medical content in XML, produce interactive media in multiple formats,and develop software. This report describes Healthwise’s learning experience for Agile adoption across multi-disciplinary teams, the measurable results, and how Agile supports the Healthwise culture.