Contribution of exploratory methods to the investigation of extended large-scale brain networks in functional MRI: methodologies, results, and challenges

Authors:
V. Perlbarg;G. Marrelec
Affiliations:
Inserm, Paris, France and Faculté de Médecine Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France;Inserm, Paris, France and Faculté de Médecine Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France
Venue:
Journal of Biomedical Imaging - Recent Advances in Neuroimaging Methodology
Year:
2008

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Abstract

A large-scale brain network can be defined as a set of segregated and integrated regions, that is, distant regions that share strong anatomical connections and functional interactions. Data-driven investigation of such networks has recently received a great deal of attention in blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI). We here review the rationale for such an investigation, the methods used, the results obtained, and also discuss some issues that have to be faced for an efficient exploration.