Design patterns: elements of reusable object-oriented software
Design patterns: elements of reusable object-oriented software
Overview and utilization of the NCI Thesaurus: Conference Papers
Comparative and Functional Genomics
Modeling a description logic vocabulary for cancer research
Journal of Biomedical Informatics
Web ontology segmentation: analysis, classification and use
Proceedings of the 15th international conference on World Wide Web
The foundational model of anatomy in OWL: Experience and perspectives
Web Semantics: Science, Services and Agents on the World Wide Web
NCI Thesaurus: A semantic model integrating cancer-related clinical and molecular information
Journal of Biomedical Informatics
Using OWL to model biological knowledge
International Journal of Human-Computer Studies
Reasoning and change management in modular ontologies
Data & Knowledge Engineering
Translating the Foundational Model of Anatomy into OWL
Web Semantics: Science, Services and Agents on the World Wide Web
Ontology design patterns for semantic web content
ISWC'05 Proceedings of the 4th international conference on The Semantic Web
A framework for ontology evolution in collaborative environments
ISWC'06 Proceedings of the 5th international conference on The Semantic Web
Oncology ontology in the NCI thesaurus
AIME'05 Proceedings of the 10th conference on Artificial Intelligence in Medicine
Using semantic web technologies for clinical trial recruitment
ISWC'10 Proceedings of the 9th international semantic web conference on The semantic web - Volume Part II
Terminology representation guidelines for biomedical ontologies in the semantic web notations
Journal of Biomedical Informatics
Computer Methods and Programs in Biomedicine
Ontologies and terminologies: Continuum or dichotomy?
Applied Ontology - Ontologies and Terminologies: Continuum or Dichotomy?
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The National Cancer Institute's (NCI) Thesaurus is a biomedical reference ontology. The NCI Thesaurus is represented using description logic, more specifically Ontylog, a description logic implemented by Apelon, Inc. We are exploring the use of the DL species of the Web Ontology Language (OWL DL) - a W3C recommended standard for ontology representation - instead of Ontylog for representing the NCI Thesaurus. We have studied the requirements for knowledge representation of the NCI Thesaurus, and considered how OWL DL (and its implementation in Protégé-OWL) satisfies these requirements. In this paper, we discuss the areas where OWL DL was sufficient for representing required components, where tool support that would hide some of the complexity and extra levels of indirection would be required, and where language expressiveness is not sufficient given the representation requirements. Because many of the knowledge-representation issues that we encountered are very similar to the issues in representing other biomedical terminologies and ontologies in general, we believe that the lessons that we learned and the approaches that we developed will prove useful and informative for other researchers.