Theoretical and Empirical Analysis of ReliefF and RReliefF
Machine Learning
Minimum reference set based feature selection for small sample classifications
Proceedings of the 24th international conference on Machine learning
Development of Two-Stage SVM-RFE Gene Selection Strategy for Microarray Expression Data Analysis
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
A review of feature selection techniques in bioinformatics
Bioinformatics
A study of cross-validation and bootstrap for accuracy estimation and model selection
IJCAI'95 Proceedings of the 14th international joint conference on Artificial intelligence - Volume 2
Gene selection from microarray data for cancer classification-a machine learning approach
Computational Biology and Chemistry
Text Mining in Bioinformatics: Research and Application
International Journal of Information Retrieval Research
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Classification using microarray gene expression data is an important task in bioinformatics. Due to the high dimensionality and small sample size that characterizes microarray data, there has recently been a drive to incorporate any available information in addition to the expression data in the classification process. As a result, much work has begun on selecting biological pathways that are closely related to a clinical outcome of interest using the gene expression data, and incorporating this pathway information opens up new avenues for classification. As opposed to previous approaches that consider individual genes as features, we propose a new approach that treats biological pathways as features. Each pathway found to be significantly related to an outcome of interest is treated as a feature, and is mapped to a feature value. We define several methods for mapping pathways to features, and compare the performance of several classifiers using our feature transformations to that of the classifiers using individual genes as features for different feature selection methods.