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Biomedical and bioinformatics applications manage and process huge datasets and are characterized by complex workflows involving the application of different algorithms and tools. In the last years the application of high-throughput technological platforms, such mass spectrometry or medical imaging, and the combined use of different databases (e.g. disease-specific databases), is producing an ever increasing volume of data that need to be processed in an efficient way. Thus, the need for scalable solutions at the different layers of biomedical/bioinformatics applications arises. The paper discusses some emerging scalable solutions for relevant biomedical and bioinformatics applications.