Integration of Genomic, Proteomic and Biomedical Information on the Semantic Web

  • Authors:

  • Bill Andreopoulos;Aijun An;Xiangji Huang;Dirk Labudde

  • Affiliations:

  • Biotechnological Centre, Technische Universität Dresden Email: williama@biotec.tu-dresden.de, Germany and Dept. of Computer Science and Engineering, York University, Toronto, Canada;Dept. of Computer Science and Engineering, York University, Toronto, Canada;Dept. of Computer Science and Engineering, York University, Toronto, Canada;Biotechnological Centre, Technische Universität Dresden Email: williama@biotec.tu-dresden.de, Germany

  • Venue:
  • ER '08 Proceedings of the ER 2008 Workshops (CMLSA, ECDM, FP-UML, M2AS, RIGiM, SeCoGIS, WISM) on Advances in Conceptual Modeling: Challenges and Opportunities
  • Year:
  • 2008

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Abstract

Researchers are faced with the challenge of integrating, on the basis of a common semantic web framework, the information on biological processes resulting from genomic and proteomic experimental studies. Researchers would like to integrate the biological processes' roles in larger medical conditions, by taking account of the time dimension. This integration will support automated analysis and reasoning on the semantic web. We address these challenges by proposing the IGIPI framework, standing for "Integrating Gene Interactions and Protein Interactions". IGIPI views different experimental studies as pieces of a puzzle that, if positioned properly, will contribute to a more complete representation of a biological process or medical condition over time. By representing the relative time points of events, this framework represents a biological process based on howit might be observed in an experiment over time. IGIPI involves integrating different ontologies and vocabularies, such as GO and UMLS/MeSH. We applied IGIPI to yeast and cancer examples. Availability: http://www.cse.yorku.ca/~billa/IGIPI/