The role of the hippocampus in solving the Morris water maze
Neural Computation
2005 Special issue: Hippocampal mechanisms for the context-dependent retrieval of episodes
Neural Networks - Special issue: Computational theories of the functions of the hippocampus
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Interactions of hippocampal and parahippocampal regions are important for memory-guided behavior. Understanding the role of these structures requires understanding the interaction of populations of neurons, including the cellular properties of neurons in structures such as the entorhinal cortex. Recent data and modeling suggest an important role for cellular mechanisms of persistent spiking and membrane potential oscillations in medial entorhinal cortex, both in mechanisms for spatial navigation and for episodic memory function. Both persistent firing and membrane potential oscillations may provide mechanisms for path integration at a cellular level based on speed-modulated head direction as a velocity signal. This path integration process thereby provides a potential mechanism for grid cell firing properties in medial entorhinal cortex. Incorporation of these processes into a larger scale model allows simulation of mechanisms for sequence encoding and episodic memory.