Optimal Feature Selection Applied to Multispectral Fluorescence Imaging

  • Authors:
  • Tobias C. Wood;Surapa Thiemjarus;Kevin R. Koh;Daniel S. Elson;Guang-Zhong Yang

  • Affiliations:
  • Institute of Biomedical Engineering, Imperial College London,;Institute of Biomedical Engineering, Imperial College London,;Institute of Biomedical Engineering, Imperial College London,;Institute of Biomedical Engineering, Imperial College London, and Department of Biosurgery and Surgical Technology, Imperial College London,;Institute of Biomedical Engineering, Imperial College London,

  • Venue:
  • MICCAI '08 Proceedings of the 11th International Conference on Medical Image Computing and Computer-Assisted Intervention, Part II
  • Year:
  • 2008

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Abstract

Recent rapid developments in multi-modal optical imaging have created a significant clinical demand for its in vivo - in situapplication. This offers the potential for real-time tissue characterization, functional assessment, and intra-operative guidance. One of the key requirements for in vivoconsideration is to minimise the acquisition window to avoid tissue motion and deformation, whilst making the best use of the available photons to account for correlation or redundancy between different dimensions. The purpose of this paper is to propose a feature selection framework to identify the best combination of features for discriminating between different tissue classes such that redundant or irrelevant information can be avoided during data acquisition. The method is based on a Bayesian framework for feature selection by using the receiver operating characteristic curves to determine the most pertinent data to capture. This represents a general technique that can be applied to different multi-modal imaging modalities and initial results derived from phantom and ex vivotissue experiments demonstrate the potential clinical value of the technique.