Probabilistic Anatomo-Functional Parcellation of the Cortex: How Many Regions?

  • Authors:
  • Alan Tucholka;Bertrand Thirion;Matthieu Perrot;Philippe Pinel;Jean-François Mangin;Jean-Baptiste Poline

  • Affiliations:
  • CEA Saclay, Neurospin/LNAO, Bât 145, Gif-sur-Yvette cedex, France 91191 and INRIA Saclay-Île-de-France, Parietal, France;INRIA Saclay-Île-de-France, Parietal, France;CEA Saclay, Neurospin/LNAO, Bât 145, Gif-sur-Yvette cedex, France 91191;INSERM UNICOG, Neurospin, Paris, France;CEA Saclay, Neurospin/LNAO, Bât 145, Gif-sur-Yvette cedex, France 91191;CEA Saclay, Neurospin/LNAO, Bât 145, Gif-sur-Yvette cedex, France 91191

  • Venue:
  • MICCAI '08 Proceedings of the 11th International Conference on Medical Image Computing and Computer-Assisted Intervention, Part II
  • Year:
  • 2008

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Abstract

Understanding brain structure and function entails the inclusion of anatomical and functional information in a common space, in order to study how these different informations relate to each other in a population of subjects. In this paper, we revisit the parcellation model and explicitly combine anatomical features, i.e. a segmentation of the cortex into gyri, with a functional information under the form of several cortical maps, which are used to further subdivide the gyri into functionally consistent regions. A probabilistic model is introduced, and the parcellation model is estimated using a Variational Bayes approach. The number of regions in the model is validated based on cross-validation. It is found that about 250 patches of cortex can be delineated both in the left and right hemisphere based on this procedure.