Establishing the credibility of a biotech simulation model

  • Authors:
  • Lenrick Johnston;Lee Schruben;Arden Yang;David Zhang

  • Affiliations:
  • University of California at Berkeley, CA;University of California at Berkeley, CA;Genentech Inc., South San Francisco, CA;Bioproduction Group Inc., Berkeley, CA

  • Venue:
  • Proceedings of the 40th Conference on Winter Simulation
  • Year:
  • 2008

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Abstract

One of the key goals for a simulation model is to accurately replicate the real system under consideration. A protocol is proposed to add credibility to the outputs of a simulation, using a double-blind method. Experimental design is outlined to maximize the value of the information obtained. Finally, experiences implementing the method for a large-scale biotech manufacturing facility are discussed.