Comparative analysis of cell parameter groups for breast cancer detection

  • Authors:

  • David Blokh;Ilia Stambler;Elena Afrimzon;Max Platkov;Yana Shafran;Eden Korech;Judith Sandbank;Naomi Zurgil;Mordechai Deutsch

  • Affiliations:

  • The Biophysical Interdisciplinary Jerome Schottenstein Center for the Research and the Technology of the Cellome, Department of Physics, Bar-Ilan University, Ramat Gan 52900, Israel;The Biophysical Interdisciplinary Jerome Schottenstein Center for the Research and the Technology of the Cellome, Department of Physics, Bar-Ilan University, Ramat Gan 52900, Israel;The Biophysical Interdisciplinary Jerome Schottenstein Center for the Research and the Technology of the Cellome, Department of Physics, Bar-Ilan University, Ramat Gan 52900, Israel;The Biophysical Interdisciplinary Jerome Schottenstein Center for the Research and the Technology of the Cellome, Department of Physics, Bar-Ilan University, Ramat Gan 52900, Israel;The Biophysical Interdisciplinary Jerome Schottenstein Center for the Research and the Technology of the Cellome, Department of Physics, Bar-Ilan University, Ramat Gan 52900, Israel;The Biophysical Interdisciplinary Jerome Schottenstein Center for the Research and the Technology of the Cellome, Department of Physics, Bar-Ilan University, Ramat Gan 52900, Israel;Department of Pathology and Cytology, Assaf Harofeh Medical Center, Zerifin 70300, Israel;The Biophysical Interdisciplinary Jerome Schottenstein Center for the Research and the Technology of the Cellome, Department of Physics, Bar-Ilan University, Ramat Gan 52900, Israel;The Biophysical Interdisciplinary Jerome Schottenstein Center for the Research and the Technology of the Cellome, Department of Physics, Bar-Ilan University, Ramat Gan 52900, Israel

  • Venue:
  • Computer Methods and Programs in Biomedicine
  • Year:
  • 2009

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Abstract

We present a method for the comparative analysis of parameter groups according to their correlation to disease. The theoretical basis of the proposed method is Information Theory and Nonparametric Statistics. Normalized mutual information is used as the measure of correlation between parameters, and statistical conclusions are based on ranking. The fluorescence polarization (FP) parameter is considered as the principal diagnostic characteristic. The FP was measured in fluorescein diacetate (FDA)-stained individual peripheral blood mononuclear cells (PBMC), derived from healthy subjects and breast cancer (BC) patients, under different stimulation conditions: by tumor tissue, the mitogen phytohemagglutinin (PHA) or without the stimulants. The FP parameters were grouped according to their correlation with breast cancer. It was established that the greatest difference between cells of BC patients and healthy subjects is found in the PHA test (parameter P1).