Convergence Properties of the Nelder--Mead Simplex Method in Low Dimensions
SIAM Journal on Optimization
Computers in Biology and Medicine
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This study analyzed the exponential decay characteristic of the harmonic peaks in the spectrum of blood pressure wave (BPW) from radial artery at wrist. Low-order harmonic deviation (LHD), high-order harmonic deviation (HHD), total harmonic deviation (THD) and exponent (@a) were developed to assess the exponential decay feature of normal subjects (N group) and the patients with palpitation (P group). The statistical results indicate that only the HHD (p value=0.010.05), THD (p value=0.220.05) and @a (p value=0.230.05) make no significant differences. The results imply that the spectral harmonic peaks for patient subjects exhibit more severe deviations in high-order harmonics along the exponential decay curve than those for normal subjects. In conclusion, this paper proposes a novel viewpoint to observe how the heart distributes blood into arterial system under normal and abnormal situations in spectral domain.