Reduction of noise due to systematic uncertainties in 113mIn SPECT imaging using information theory

  • Authors:
  • P. T. Krishna Kumar;Vir V. Phoha;S. S. Iyengar;Puneeth Iyengar

  • Affiliations:
  • Room No. 114, Central Design Office, Indira Gandhi Centre for Atomic Research, Kalpakkam 603 102, India;College of Engineering and Science, Louisiana Tech University, Nethken Hall, Arizona Ave., Ruston, LA 71272, USA;Department of Computer Science, Louisiana State University, Baton Rouge, LA 70803, USA;Division of Radiation Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA

  • Venue:
  • Computers in Biology and Medicine
  • Year:
  • 2009

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Abstract

SPECT images using radiopharmaceuticals are limited by noise caused by both random and systematic uncertainties. All the efforts so far have been directed only to minimize the random uncertainty and no attempt has ever been made to minimize the noise due to systematic uncertainty. As these radiopharmaceuticals encounter many systematic uncertainties during their formation, we constructed the covariance matrix with some of these systematic uncertainties for the gamma count rate of ^1^1^3^mIn. We describe the algorithm we have developed based on the technique of determinant inequalities and the concept of minimization of mutual information to process the covariance matrix element by element to minimize the noise caused by systematic uncertainty in the SPECT imaging of ^1^1^3^mIn and its utility to experimentalists to design and improve their process of measurement and instrumentation.