A calculus of mobile processes, I
Information and Computation
Information Processing Letters
Cell Cycle Control in Eukaryotes: A BioSpi model
Electronic Notes in Theoretical Computer Science (ENTCS)
Petri net modelling of biological regulatory networks
Journal of Discrete Algorithms
Formal Executable Models of Cell Signaling Primitives
ISOLA '06 Proceedings of the Second International Symposium on Leveraging Applications of Formal Methods, Verification and Validation
Efficient, correct simulation of biological processes in the stochastic pi-calculus
CMSB'07 Proceedings of the 2007 international conference on Computational methods in systems biology
Petri nets for systems and synthetic biology
SFM'08 Proceedings of the Formal methods for the design of computer, communication, and software systems 8th international conference on Formal methods for computational systems biology
Incorporating time delays into the logical analysis of gene regulatory networks
CMSB'06 Proceedings of the 2006 international conference on Computational Methods in Systems Biology
Gene regulation in the pi calculus: simulating cooperativity at the lambda switch
Transactions on Computational Systems Biology VII
The attributed pi-calculus with priorities
Transactions on Computational Systems Biology XII
Hi-index | 0.00 |
In this paper, we address the problem of modeling biological regulatory networks thanks to the stochastic π -calculus. We propose a method which extends a logical method, that is the approach of René Thomas. By introducing temporal and stochastic aspects there, we make our formalism closer to biological reality. We then use the SPiM stochastic simulator to illustrate the practical interests of this description. The application example concerns the behaviors of four interacting genes involved in the λ -phage. Interesting results are emerging from the simulations. First, it confirms knowledge of the regulation phenomena. In addition, experiments with different values of the delay parameters give some precious hints of a tendency either for the lytic phase or to the lysogenic phase.