The Bayesian group-Lasso for analyzing contingency tables

  • Authors:
  • Sudhir Raman;Thomas J. Fuchs;Peter J. Wild;Edgar Dahl;Volker Roth

  • Affiliations:
  • University of Basel, Basel, Switzerland;ETH Zurich, Zurich, Switzerland & Competence Center for Systems Physiology and Metabolic Diseases, Zurich, Switzerland;University Hospital Zurich, Zurich, Switzerland;University Hospital, Aachen, Germany;University of Basel, Basel, Switzerland

  • Venue:
  • ICML '09 Proceedings of the 26th Annual International Conference on Machine Learning
  • Year:
  • 2009

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Abstract

Group-Lasso estimators, useful in many applications, suffer from lack of meaningful variance estimates for regression coefficients. To overcome such problems, we propose a full Bayesian treatment of the Group-Lasso, extending the standard Bayesian Lasso, using hierarchical expansion. The method is then applied to Poisson models for contingency tables using a highly efficient MCMC algorithm. The simulated experiments validate the performance of this method on artificial datasets with known ground-truth. When applied to a breast cancer dataset, the method demonstrates the capability of identifying the differences in interactions patterns of marker proteins between different patient groups.