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This paper describes a mixed-signal VLSI design utilizing the controlled conductance properties of MOSFETs, for the RF filter of mobile communication and the biologically plausible neuromorphic hardware. The programmable linear conductance is realized by the pair of MOSFETs in the triode region, and it produces the voltage-controlled tunable function with the demonstration in the areas of tunable analogue VLSI for RF communication and electronic neurons of biologically plausible characteristics. The transconductance amplifier based on the proposed MOSFET conductance has the bandwidth over 6 GHz and illustrated the hardware implementation of the biologically plausible neurons of Hodgkin-Huxley formalism.