From Intracardiac Electrograms to Electrocardiograms: Models and Metamodels

Authors:
Géraldine Ebrard;Miguel A. Fernández;Jean-Frédéric Gerbeau;Fabrice Rossi;Nejib Zemzemi
Affiliations:
INRIA Paris, Le Chesnay Cedex, France F---78153;INRIA Paris, Le Chesnay Cedex, France F---78153;INRIA Paris, Le Chesnay Cedex, France F---78153;Institut TELECOM, TELECOM ParisTech, LTCI --- UMR CNRS 5141, Paris F---75013;INRIA Paris, Le Chesnay Cedex, France F---78153 and Laboratoire de mathématiques d'Orsay, Université Paris 11, Orsay Cedex, France F-91405
Venue:
FIMH '09 Proceedings of the 5th International Conference on Functional Imaging and Modeling of the Heart
Year:
2009

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Abstract

We consider the problem of building a standard electrocardiogram (ECG) from the electrical potential provided by a pacemaker in a few points of the heart (electrogram). We use a 3D mathematical model of the heart and the torso electrical activity, able to generate "computational ECG", and a "metamodel" based on a kernel ridge regression. The input of the metamodel is the electrogram, its output is the ECG. The 3D model is used to train and test the metamodel. We illustrate the performance of the proposed strategy on simulated bundle branch blocks of various severities and a few clinical data.