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Many important scientific, engineering and financial applications can benefit from offloading computation to emerging parallel systems, such as the Cell Broadband EngineTM(Cell/B.E.). However, traditional remote procedure call (RPC) mechanisms require significant investment of time and effort to rewrite applications to use a specific RPC system. As a result, offloading functions to remote systems is not viable for many applications. IBM® Dynamic Application Virtualization TM(DAV) insulates the application developer by automatically generating stub libraries that allow direct calling of remote procedures without application source code modification. In this paper, we describe DAV automates the conversion of client applications to use remote procedure calls. DAV can generate stub libraries for a wide variety of client applications running on a variety of architectures, allowing allows simple and fast remote procedure call enablement of applications with minimum programming effort.