Evolving biochemical reaction networks with stochastic attributes

  • Authors:
  • Thomas R. Kiehl

  • Affiliations:
  • Rensselaer Polytechnic Institute, Troy, NY, USA

  • Venue:
  • Proceedings of the 11th Annual Conference Companion on Genetic and Evolutionary Computation Conference: Late Breaking Papers
  • Year:
  • 2009

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Abstract

Biochemical networks display a wide range of behaviors. While many of these networks tend to operate in a steady-state regime, others exhibit distinctly stochastic behaviors. Fitting models to data from these systems challenges many of the linear and steady-state assumptions of typical modeling techniques. The genetic algorithm described herein seeks to generate networks which exhibit desired average/steady-state behaviors while minimizing or maximizing the standard deviation of those behaviors.