Extracting regulatory gene expression networks from PubMed
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We explore a rule system and a machine learning (ML) approach to automatically harvest information on gene regulation events (GREs) from biological documents in two different evaluation scenarios -- one uses self-supplied corpora in a clean lab setting, while the other incorporates a standard reference database of curated GREs from RegulonDB, real-life data generated independently from our work. In the lab condition, we test how feasible the automatic extraction of GREs really is and achieve F-scores, under different, not directly comparable test conditions though, for the rule and the ML systems which amount to 34% and 44%, respectively. In the RegulonDB condition, we investigate how robust both methodologies are by comparing them with this routinely used database. Here, the best F-scores for the rule and the ML systems amount to 34% and 19%, respectively.