Classification of SPECT Images of Normal Subjects versus Images of Alzheimer's Disease Patients
MICCAI '01 Proceedings of the 4th International Conference on Medical Image Computing and Computer-Assisted Intervention
BIBE '04 Proceedings of the 4th IEEE Symposium on Bioinformatics and Bioengineering
IEEE Transactions on Pattern Analysis and Machine Intelligence
Knowledge and Information Systems - Special Issue on Mining Low-Quality Data
Journal of Cognitive Neuroscience
Effective Emission Tomography Image Reconstruction Algorithms for SPECT Data
ICCS '08 Proceedings of the 8th international conference on Computational Science, Part I
Expert Systems with Applications: An International Journal
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An accurate and early diagnosis of the Alzheimer's Disease (AD) is of fundamental importance for the patients medical treatment. Single Photon Emission Computed Tomography (SPECT) images are commonly used by physicians to assist the diagnosis, rating them by visual evaluations. In this work we present a computer assisted diagnosis tool based on a Principal Component Analysis (PCA) dimensional reduction of the feature space approach and a Support Vector Machine (SVM) classification method for improving the AD diagnosis accuracy by means of SPECT images. The most relevant image features were selected under a PCA compression, which diagonalizes the covariance matrix, and the extracted information was used to train a SVM classifier which could classify new subjects in an unsupervised manner.