Small Sample Size Effects in Statistical Pattern Recognition: Recommendations for Practitioners
IEEE Transactions on Pattern Analysis and Machine Intelligence
A decision-theoretic generalization of on-line learning and an application to boosting
Journal of Computer and System Sciences - Special issue: 26th annual ACM symposium on the theory of computing & STOC'94, May 23–25, 1994, and second annual Europe an conference on computational learning theory (EuroCOLT'95), March 13–15, 1995
Expected classification error of the Fisher linear classifier with pseudo-inverse covariance matrix
Pattern Recognition Letters
Advances in kernel methods: support vector learning
Advances in kernel methods: support vector learning
Fast training of support vector machines using sequential minimal optimization
Advances in kernel methods
Support Vector Machines for Texture Classification
IEEE Transactions on Pattern Analysis and Machine Intelligence
Classification of SPECT Images of Normal Subjects versus Images of Alzheimer's Disease Patients
MICCAI '01 Proceedings of the 4th International Conference on Medical Image Computing and Computer-Assisted Intervention
Survey of clustering algorithms
IEEE Transactions on Neural Networks
Exploratory matrix factorization for PET image analysis
HAIS'10 Proceedings of the 5th international conference on Hybrid Artificial Intelligence Systems - Volume Part I
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We present a novel classification method of SPECT images based on clustering for the diagnosis of Alzheimer's disease. The aims of the clustering approach which is based on Gaussian Mixture Model (GMM) for density estimation, is to automatically select Regions of Interest (ROIs) and to effectively reduce the dimensionality of the problem. The clusters represented by Gaussians are constructed according to a maximum likelihood criterion employing the expectation maximization (EM) algorithm. By considering only the intensity levels inside the clusters, the resulting feature space has a significantly reduced dimensionality with respect to former approaches using the voxel intensities directly as features. With this feature extraction method one avoids the so-called small sample size problem and nonlinear classifiers may be used to distinguish between the brain images of normal and Alzheimer patients. Our results show that for various classifiers the clustering method yields higher accuracy rates than the classification considering all voxel values.