Computational Biology and Chemistry
Information-theoretic analysis of molecular (co)evolution using graphics processing units
Proceedings of the 3rd international workshop on Emerging computational methods for the life sciences
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Summary: InterMap3D predicts co-evolving protein residues and plots them on the 3D protein structure. Starting with a single protein sequence, InterMap3D automatically finds a set of homologous sequences, generates an alignment and fetches the most similar 3D structure from the Protein Data Bank (PDB). It can also accept a user-generated alignment. Based on the alignment, co-evolving residues are then predicted using three different methods: Row and Column Weighing of Mutual Information, Mutual Information/Entropy and Dependency. Finally, InterMap3D generates high-quality images of the protein with the predicted co-evolving residues highlighted. Availability: http://www.cbs.dtu.dk/services/InterMap3D/ Contact: gorm@cbs.dtu.dk